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A stunning arch
connects old and new exhibit areas at the Washington State
Convention and Trade Center. Set in the heart of downtown
Seattle, the center is within easy walking distance of more than
6,000 hotel rooms. Photo: Tim Thompson |
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The Public
Market sign hovers over the Pike Place Market, with Elliott Bay,
Puget Sound and West Seattle in the background. Photo: Tim
Thompson |
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Residents and
tourists enjoy a sunny Seattle day at one of the many
restaurants on Seattle's bustling waterfront. A Washington State
Ferry unloads and loads passengers at the Colman Dock. Photo:
Tim Thompson |
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Boats move in and out of the Bell Harbor Marina, with the
Seattle skyline as a backdrop. Photo: Tim Thompson |
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Seattle has many great locales for outdoor activities. Alki
Beach Park in West Seattle is a scenic location to run, bike or
rollerblade, with Elliott Bay and the Seattle skyline serving as
backdrops. Photo: Tim Thompson |
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As part of the City
of Seattle's public arts program, The Seattle Arts Commission
installed Hammering Man on September 12, 1992, at the entrance
to the Robert Venturi designed Seattle Art Museum at First
Avenue and University Street. Photo: Tim Thompson |
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AAI PROGRAM |
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Except where noted, sessions are at the Washington
State Convention & Trade Center (WSCTC) |
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PRESIDENT'S PROGRAM |
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Dr. Weiss |
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AAI President's Address
Generously supported by
Genentech,
Inc.
Friday, May 8, 5:00 PM
—
WSCTC Room 6BC
Arthur Weiss,
HHMI, University of California, San Francisco, AAI
President
TCR signal transduction: opening the black box
Gary A. Koretzky, University of Pennsylvania
School of Medicine, Introduction |
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Dr.
Burakoff |
Presentation of the AAI
Lifetime Achievement Award
Friday, May 8, 5:00 PM
—
WSCTC Room 6BC
Chair: Arthur Weiss, HHMI, University of
California, San Francisco, AAI President
Award Recipient:
Steven J. Burakoff, The Tisch Cancer Institute,
Mount Sinai Medical Center |
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The AAI Lifetime Achievement Award is the highest
honor bestowed by the AAI Council upon an AAI
member. This award recognizes a deserving member for
a career of scientific achievement and for
contributions to AAI and fellow immunologists. The
award will be presented prior to the start of the
AAI Presidential Address. |
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AAI President's Symposium
—
Signaling by Antigen Receptors: From Molecules to Models
Monday, May 11, 2:30 PM
—
WSCTC Room 6BC
Chair:
Arthur Weiss,
HHMI, University of California, San Francisco, AAI
President
Speakers
·
Lawrence E. Samelson, NCI, NIH, Signaling at
the T cell antigen receptor
·
Gary A. Koretzky, University of Pennsylvania
School of Medicine, Regulation of immune cell
development and function by adapter proteins
·
Doreen A. Cantrell, University of Dundee,
Matching lymphocyte metabolism and migration
·
Arup
K. Chakraborty, Massachusetts Institute of
Technology, Molecular origin
and functional consequences of digital signaling in
lymphocytes
Dr. Weiss |
Dr.
Samelson |
Dr. Koretzky |
Dr. Cantrell |
Dr.
Chakraborty |
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Dr. Baltimore |
Presentation of the AAI
Excellence in Mentoring Award
Monday, May 11, 2:30 PM
—
WSCTC Room 6BC
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Chair: Arthur Weiss,
HHMI, University of California, San Francisco, AAI
President |
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Award
Recipient:
David Baltimore, California Institute of
Technology |
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Frederick W. Alt, HHMI, Children's
Hospital Boston, CBR Institute, Harvard Medical
School, Introduction |
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The AAI Excellence in Mentoring Award recognizes an
AAI member's exemplary career contributions to a
future generation of scientists.
The award will be presented prior to the start of
the AAI Presidential Symposium.
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AAI DISTINGUISHED
LECTURES |
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Generously supported by
eBioscience, Inc. |
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Saturday, May 9, 5:00 PM
—
WSCTC Room 6BC
Megan Sykes, Massachusetts General Hospital and
Harvard Medical School, Controlling the alloresponse:
between benches, to the bedside and back |
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Sunday, May 10, 5:00 PM
—
WSCTC Room 6BC
John C. Cambier, University of Colorado Denver
School of Medicine and National Jewish Health, Anergy
vs. activation: the B cell antigen receptor as a
molecular switch |
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Monday, May 11, 5:00 PM
—
WSCTC Room 6BC
Alexander Y. Rudensky, HHMI, Memorial
Sloan-Kettering Cancer Center, Foxp3: a key to
dominant tolerance |
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MAJOR SYMPOSIA |
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Saturday, May 9 —
8:00 - 11:30 AM |
Major Symposium A:
Triggers of Autoimmunity
WSCTC Room 6E
Chair: Joanne L. Viney, Amgen Corporation
Co-Chair: Dale T. Umetsu, Children’s Hospital
Boston and Harvard Medical School
Speakers
·
Joanne L. Viney,
Amgen Corporation, Triggers of intestinal
inflammation
·
Dale T. Umetsu,
Children’s Hospital Boston and Harvard Medical School,
IL-17-producing natural killer T cells in the lungs
·
Joan M. Goverman,
University of Washington, Th17 and Th1 cells in CNS
autoimmunity
·
Nicholas P. Restifo,
NCI, NIH, Triggering autoimmunity with cancer
therapeutics
·
Alexander V. Chervonsky,
University of Chicago, Commensal bacteria and type 1
diabetes
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Sarkis K. Mazmanian,
California Institute of Technology, Dysbiosis as a
trigger for autoimmune colitis and systemic inflammation |
Major Symposium B: The
Inflammasome
WSCTC Room 6B
Chair: Gabriel Núñez, University of Michigan
Co-Chair: Jonathan A. Harton, Albany Medical
College
Speakers
·
Gabriel Núñez,
University of Michigan Cancer Center, Activation of
the inflammasome by bacterial pathogens
·
Jenny P.Y. Ting,
University of North Carolina Lineberger Comprehensive
Cancer Center, Genetic and functional analysis of NLR
genes
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Vishva M. Dixit,
Genentech, Inc., The cryopyrin/NALP3 inflammasome
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Jonathan A. Harton,
Albany Medical College, Pyrin-only
proteins: regulators of the inflammasome
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Fayyaz S. Sutterwala,
University of Iowa, Sterile inflammatory responses
mediated by the NLRP3 inflammasome
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Eicke Latz,
University of Massachusetts Medical School,
Activation of the NALP3 inflammasome by lysosomal damage |
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Sunday, May 10 —
8:00 - 11:30 AM |
Major Symposium C:
Bridging Adaptive and Innate Immunity
WSCTC Room 6E
Generously supported by
Kyowa Hakko Kirin
California, Inc.
Chair: Hilde Cheroutre, La Jolla Institute for
Allergy and Immunology
Co-Chair: Youhai H. Chen, University of
Pennsylvania School of Medicine
Speakers
·
Carla V. Rothlin,
Salk Institute, TAMing inflammation: introducing a
novel anti-inflammatory receptor tyrosine kinase
signaling pathway
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Youhai H. Chen,
University of Pennsylvania School of Medicine,
Toll-like receptor signaling: gene- and signal-specific
regulators
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Eugene C. Butcher,
Stanford University, Chemoattractant receptors at the
interface of innate and adaptive immunity
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Wendy L. Havran,
The Scripps Research Institute, Crosstalk between
gamma-delta T cells and their epithelial neighbors
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Hilde Cheroutre,
La Jolla Institute for Allergy and Immunology,
Mucosal immunity: it is all a matter of "gut" decisions
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Randolph J. Noelle,
Dartmouth Medical School, Regulation of peripheral
tolerance in transplantation and cancer |
Major Symposium D:
MicroRNAs
WSCTC Room 6B
Chair: Judy Lieberman,
Immune Disease Institute and
Harvard Medical School
Co-Chair: K. Mark Ansel, University of
California, San Francisco
Speakers
·
K. Mark Ansel,
University of California, San Francisco, MicroRNA
homeostasis in lymphocytes
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Joshua Mendell,
Johns Hopkins University School of Medicine, MicroRNA
reprogramming by oncogenes and tumor suppressors
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Judy Lieberman,
Immune Disease Institute and Harvard Medical School,
Silencing cell proliferation
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Chang-Zheng Chen,
Stanford University School of Medicine, Micromanaging
immune systems by the miR-181 family genes
·
Jeffrey A. Bluestone,
University of California, San Francisco, Role of
microRNAs in autoimmunity: a key role in regulatory and
memory T cell function
·
David Baltimore,
California Institute of Technology, MicroRNAs and
immunity |
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Monday, May 11 —
8:00 - 11:30 AM |
Major Symposium E:
Epigenetic Regulation of the
Immune Response
WSCTC Room 6E
Chair: Ann J. Feeney, The Scripps Research
Institute
Co-Chair: Stephen T. Smale, University of
California, Los Angeles
Speakers
·
Ann J. Feeney,
The Scripps Research Institute, Epigenetic regulation
of immunoglobulin gene recombination
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Cornelis Murre,
University of California, San Diego, The 3-D
structure of the immunoglobulin heavy chain locus:
implications for the generation of antibody diversity
·
Michael S. Krangel, Duke University Medical
Center, Epigenetic regulation of TCR gene assembly
·
Amy S. Weinmann,
University of Washington, The role for T-box proteins
in establishing epigenetic states in immune cells
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Stephen T. Smale,
University of California, Los Angeles, Selective
regulation of pro-inflammatory genes by chromatin
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Christopher B. Wilson,
University of Washington, Epigenetic regulation of T
helper cell differentiation and function |
Major Symposium F: T
Cell Response to Pathogens
WSCTC Room 6B
Chair: Michael J. Bevan, HHMI, University of
Washington, Seattle
Co-Chair: Marcia A. Blackman, Trudeau Institute
Speakers
·
John T. Harty,
University of Iowa, CD8+ T cell immunity
to microbes
·
Marcia A. Blackman, Trudeau Institute, The
impact of aging on T cell repertoire and immunity to
influenza virus
·
Nilabh
Shastri, University of California, Berkeley,
Immune responses to Toxoplasma gondii
·
Francis R. Carbone, University of Melbourne, Dendritic
cells and tissue-resident T cells contribute to the
memory response during localized infections
·
David Masopust, University of Minnesota,
Memory T cells: issues of quantity, quality and location
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Cliona M. Rooney,
Baylor College of Medicine, Improving multipathogen-specific
T cell therapies |
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Tuesday, May 12 —
8:00 - 11:30 AM |
Major Symposium G:
IL-23/IL-17 Axis in T Cell Differentiation and Tissue
Inflammation
WSCTC Room 6E
Chair: Vijay K. Kuchroo, Harvard Medical School
and Brigham and Women’s Hospital
Co-Chair: Wenjun Ouyang, Genentech, Inc.
Speakers
·
Steven D. Levin,
ZymoGenetics, Inc.,
Ancillary molecules in the development and function of
Th17 cells
·
Vijay K. Kuchroo,
Harvard Medical School and Brigham and Women’s Hospital,
Reciprocal relationship between Treg and Th17 cells
·
Wenjun Ouyang,
Genentech, Inc., The functions of IL-22 and IL-17 in
autoimmune and infectious diseases
·
John J. O’Shea,
NIAMS, NIH,
Signal transduction in Th17 development
·
Sarah L. Gaffen,
University of Pittsburgh, Structure-function
relationships in the IL-17 receptor complex |
Major Symposium H: Cell
Fate Decisions in Lymphocyte Development
WSCTC Room 6B
Chair: Ellen V. Rothenberg, California Institute
of Technology
Co-Chair: Jonathan G. Kaye, Cedars Sinai Medical
Center
Speakers
·
Jonathan G. Kaye,
Cedars Sinai Medical
Center,
Multiple roles for nuclear factor TOX in development of
the immune system
·
Paul E. Love,
NICHD, NIH, A new T cell-specific protein with a
critical role in thymocyte development
·
Harald von Boehmer,
Dana-Farber Cancer Institute and Harvard Medical School,
Notch1 and c-myc in alpha beta T-lineage fate and
lymphoma
·
Nancy A. Speck,
University of Pennsylvania School of Medicine, Roles
of core binding factors (Runx/CBFb)
in hematopoietic lineage choice
·
Ellen V. Rothenberg,
California Institute of Technology, A genomic view of
T-lineage specification and commitment
·
Avinash Bhandoola,
University of Pennsylvania School of Medicine, Notch
signals constrain the myeloid potential of early thymic
progenitors |
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AWARDS |
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The AAI award programs honor
members at every career stage. AAI awards are presented
throughout the meeting in special sessions.
For
complete information on all AAI Awards, please visit
www.aai.org/Awards.
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AWARD PRESENTATIONS
AND LECTURES |
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Dr.
Banchereau |
AAI-Dana
Foundation Award in Human Immunology Research: Award
Presentation and Lecture
Generously supported by the
Dana Foundation
Saturday, May 9, 3:15 PM
—
WSCTC Room 6E
Chair:
Arthur Weiss, HHMI,
University of California, San Francisco, AAI President
Award Recipient/Lecturer:
Jacques Banchereau, Baylor Institute for
Immunology Research, Human immunology: a fertile
field for basic and patient-oriented discoveries |
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Dr. Dong |
AAI-BD
Biosciences Investigator Award Presentation and
Lecture
Generously supported by BD
Biosciences
Sunday, May 10, 2:30 PM
—
WSCTC Room 6E
Chairs:
Arthur Weiss, HHMI,
University of California, San Francisco, AAI President;
Andy Last, Vice President Global Marketing, BD
Biosciences
Award Recipient/Lecturer:
Chen Dong, The University of Texas MD Anderson
Cancer Center, Many paths of peripheral T cells |
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Dr. Bevan |
AAI-Invitrogen
Meritorious Career Award Presentation and Lecture
Generously supported by
Invitrogen Corporation
Sunday, May 10, 3:30 PM
—
WSCTC Room 6E
Chair:
Arthur Weiss, HHMI, University of California, San
Francisco, AAI President
Award Recipient/Lecturer:
Michael J. Bevan, HHMI, University of Washington,
Matching antigen strength in the thymus and periphery |
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SPECIAL EVENTS |
AAI Opening Reception
Generously sponsored by
eBioscience, Inc.
Friday, May 8, 6:00 - 7:30
PM
—
WSCTC Exhibit Hall
New this year! Immediately following the Presidential
Address, attendees are invited to the exhibit floor to
seek out friends and the many exciting new offers from
the AAI exhibitors. |
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Young Investigators Party! (YIP!)
Saturday, May 9, 9:00 - 11:00 PM
—
Grand Hyatt Seattle Hotel,
Leonesa Ballroom
This always
popular event has been scheduled for Saturday “prime
time” this year and given a new format. Young scientists
will enjoy a relaxed but festive atmosphere to meet,
network—and
dance!
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AAI Gala
Generously sponsored by
BioLegend and
Tomy Digital Biology Co., Ltd.
Sunday, May 10, 7:00 - 10:00 PM
—
Benaroya Concert Hall,
Seattle
For AAI members with invitations only (click
here for details)
Following a reception in the spectacular atrium lobby of
the Benaroya Hall, guests will enter the concert hall
for a program tailored uniquely for AAI! |
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AAI Business
Meeting and Awards Presentation
Monday, May 11, 12:45 - 2:15 PM
—
WSCTC Room 606-607
This session
will include the annual report to AAI members on AAI
and
The Journal of
Immunology business affairs and will feature
the following 2009 AAI awards presentations and
acknowledgements.
Lunch will be provided (no ticket required). |
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Dr. Monroe |
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AAI Distinguished
Service Award |
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For dedicated leadership as Chair of the
AAI Program Committee |
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(2006-2009) |
John G. Monroe, Genentech, Inc. |
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· AAI-Invitrogen
Trainee
Achievement
Award
Recipients |
· AAI Minority
Scientist
Travel Award
Recipients |
· AAI Junior Faculty
Travel Grant
Recipients |
· AAI Trainee Abstract
Award
Recipients |
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AAI
COMMITTEE-SPONSORED SESSIONS |
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Clinical Immunology Committee |
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Scourge of the Mummies:
TB Then and Now
Saturday, May 9, 10:15 AM
– 12:15 PM
—
WSCTC Room 6C
Chair:
Kathleen E. Sullivan,
Children’s Hospital of Philadelphia, Chair, AAI Clinical
Immunology Committee; Co-Chair:
Cathryn Nagler,
Massachusetts General Hospital and Harvard Medical
School, Co-Chair, AAI Clinical Immunology Committee
Speakers
Jerald C. Sadoff,
Aeras Foundation, TB vaccine development in modern
times
Joel D. Ernst,
NYU School of Medicine, Dendritic cell traffic and
antigen presentation in tuberculosis
Shabaana A. Khader,
Children’s Hospital of Pittsburgh,
T cell-mediated
immunity to tuberculosis
Samuel M.
Behar,
Brigham and Women’s Hospital and Harvard Medical School,
Lipid
mediators modulate the cellular fate of infected
macrophages and regulate innate and adaptive immunity to
tuberculosis |
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Committee on Public Affairs |
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Immunology at CDC:
Research Opportunities in Public Health
Saturday, May 9, 12:30 - 2:00 PM
—
WSCTC Room 606-607
Chair:
William R. Green,
Dartmouth Medical School, Chair, AAI Committee on Public
Affairs
Speakers
Alison C. Mawle,
Associate Director for Laboratory Science, National
Center for Immunization and Respiratory Diseases,
Coordinating Center for Infectious Diseases, Centers for
Disease Control and Prevention:
Immunology at CDC: why
it matters
Conrad Quinn,
Molecular Pathogenesis and
Immunology Team, Meningitis and Vaccine Preventable
Diseases Branch, Division of Bacterial Diseases,
National Center for Immunization and Respiratory
Diseases, Coordinating Center for Infectious Diseases,
Centers for Disease Control and Prevention:
Anthrax vaccines – from
Pasteur to pasture to PA
Ellen Kersh,
Laboratory Branch, Pre-clinical Evaluation Team,
Division of HIV/AIDS Prevention, National Center for
HIV, Hepatitis, STD and TB Prevention, Coordinating
Center for Infectious Diseases, Centers for Disease
Control and Prevention:
Immunological factors
impact susceptibility to SHIV in a macaque model of
repeated mucosal viral challenge
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Learn
about the exciting immunological research being
conducted at the CDC. Speakers will also describe
ongoing collaborative and interagency work, as well
as funding opportunities for scientists. A question
and answer period will follow the presentations.
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Good Science Gone Bad: "Dual Use" Research and How
It Affects You
Sunday, May 10, 12:30 - 2:30 PM
—
WSCTC Room 606-607
Chair:
William R. Green,
Dartmouth Medical School, Chair, AAI Committee
on Public Affairs |
Keynote Speaker
Paul S. Keim, Chair, National Science Advisory
Board on Biosecurity (NSABB) Communications Working
Group; Director of Pathogen Genomics, The
Translational Research Institute (TGen); Director,
Center for Microbial Genetics and Genomics, and The
Cowden Endowed Chair in Microbiology. Northern
Arizona University, Flagstaff AZ,
Good research for bad purposes: how to know "dual
use" research when you see it, and when you should
worry
Speakers
David A. Relman, Member,
National Science Advisory Board on Biosecurity (NSABB);
Professor of Microbiology & Immunology, and of
Medicine, Stanford University; Chief of Infectious
Diseases, VA Palo Alto Health Care System, The
future life sciences landscape: benefits and risks
David R. Franz, Co-Chair,
National Science Advisory Board on Biosecurity (NSABB)
International Working Group; Chief Biological
Scientist, Midwest Research Institute (Frederick,
MD),
Regulating
"dual-use" research: if the U.S. does, will the
world follow?
Paul S. Keim, Chair,
National Science Advisory Board on Biosecurity (NSABB)
Communications Working Group; Director of Pathogen
Genomics, The Translational Research Institute (TGen);
Director, Center for Microbial Genetics and
Genomics, and The Cowden Endowed Chair in
Microbiology, Northern Arizona University, Flagstaff
AZ,
The anthrax letter attacks: investigating the
researchers, investigating the crime |
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BIOTERRORISM!
Caused by a rogue scientist or caused, unknowingly,
by you?! Caused by
you because you
didn’t know about “dual use research” (research that
can be used for both beneficial and nefarious
purposes). This session will explore the political
and scientific issues surrounding dual use research,
its dangers and benefits
—
including its forensic role in identifying suspects
in the 2002 anthrax case
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